Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation

Chronic Low-grade Inflammation after Exercise: Controversies

chronic low-grade inflammation after exercise: controversies

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Aerobic exercise reverses arterial inflammation with aging in mice.

We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. When compared with young controls (6.2 ± 0.4 mo; n = 7), old (31.3 ± 0.5 mo; n = 11) male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the proinflammatory transcription factor NF-κB, as indicated by greater aortic phosphorylation of both the inhibitor of NF-κB kinase (I...

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Maternal obesity during pregnancy has been associated with increased risk of neurodevelopmental disorders, including autism spectrum disorder (ASD), in offspring. Here, we report that maternal high-fat diet (MHFD) induces a shift in microbial ecology that negatively impacts offspring social behavior. Social deficits and gut microbiota dysbiosis in MHFD offspring are prevented by co-housing with...

Chronic Low-grade Inflammation after Exercise: Controversies

In a recent published paper in IJBMS, Kazeem A, et al evaluated the changes of acute phase proteins after moderate and prolonged exercise (1). They found that prolonged exercise increased plasma C-reactive protein (CRP); however, moderate exercise did not change plasma CRP level. They concluded that moderate exercise, and not prolonged exercise, should be encouraged. Chronic low-grade inflammat...